Can You Die From Squamous Cell Carcinoma
Can You Die From Squamous Cell Carcinoma in America alone, hundreds of thousands of people are diagnosed with squamous cell carcinoma every year? It is the second most common form of skin cancer and can be cured very easily in addition to basal cell carcinoma – as long as it has no chance of spreading. The metastasis of squamous cell carcinoma, on the other hand, is not so easy to cure and to treat efficiently. Before metastasis, cancerous growth can often be removed with a simple surgical procedure in the doctor’s office. While there are few cases that metastasize each year, in these cases a significant number of patients die from the disease.
When skin cancer spreads
When squamous cell carcinoma spreads, it first migrates to nearby lymph nodes. From the lymph nodes, it can metastasize to other organs. In most cases, cancer spreads to the lungs, although it can spread elsewhere.
The risk of metastasis is low. It is estimated that two to six percent of cases metastases. In general, it is the high-risk cases of the disease that have this problem if they remain untreated. Factors such as age, sunlight and light skin increase the risk. Once cancer reaches the lymph nodes, the morbidity rate is significant. When squamous cell carcinoma reaches the lungs, it cannot be cured.
Can You Die From Squamous Cell Carcinoma, The best way to prevent the metastasis of squamous cell carcinoma is to take measures to reduce the overall risk of skin cancer. Limit sun exposure, do not use sunbeds, and use a natural sunscreen with a high sun protection factor in the sun to protect your skin from UVA and UVB damage. A healthy diet rich in fresh fruit and vegetables as well as whole grains prevents cancer and strengthens the immune system.
Check your skin regularly for abnormal spots, especially on the face, ears, shoulders, hands, and back. If detected early, you can easily prevent the metastasis of the tumor. Look for rough skin areas, open wounds prone to bleeding, or red, encrusted or scaly spots. If there are any signs, consult your doctor so that they can make an early diagnosis if they are actually skin cancer. Once diagnosed, they can remove cancer long before it can spread. Pay particular attention to your skin and look for red, scaly spots or wounds once a month if you are at risk of developing skin cancer due to lifetime exposure to the sun, light skin, previous problems with skin cancer or if you are over the age of fifty squamous cell carcinoma. Men are also two to three times more likely to be affected. Even if you have successfully treated squamous cell carcinoma in the past, there may be a recurrence. Therefore, always pay attention to your skin.
Squamous cell carcinomas are unlikely to metastasize. However, if this is the case, the disease is fatal in many cases, especially if it moves beyond the lymph nodes. Wear sunscreen, stay in the shade, wear a hat with a wide brim when you are in the garden for hours, and see your doctor if you see signs of cancer.
Read more: Squamous Cell Carcinoma Invasive Type
Although most squamous cell carcinomas of the skin can be easily surgically treated, a small group of patients with specific disease risk factors develop metastases and ultimately die from the disease. This was found in a retrospective study.
Among a cohort of patients treated at a single academic center, 3.7% developed node metastases and 2.1% developed the disease fatally, according to Chrysalyne D. Schmults, MD, and colleagues from Harvard University.
A consistent predictor of a poor result was a tumor diameter of 2 cm or more, which was associated with sub hazards ratios of 7 (95% CI 2.2-21.6, P -0.001) for node metastases and 15.9 (95% CI 4.8-52.3, P -0.001) for disease-specific deaths The researchers reported in the May issue of JAMA Dermatology.
A clear definition of high-risk cutaneous squamous cell carcinoma, which delimits the associated risk factors, was lacking. This is a clinically important gap, they noted.
“The prognosis is poor as soon as [distal metastases] or a locoregional recurrence develops. Therefore, it would be beneficial to determine which tumors or patients are at high risk of poor outcomes and to allow aggressive adjuvant treatment at an earlier stage of the disease,” they wrote.
In their study, the researchers reviewed all pathological reports of this skin cancer from Brigham and Women’s Hospital in Boston between 2000 and 2009 and identified 1,832 tumors in 985 patients.
Just over half of the patients were men, almost all were white, and 14.5% had immunosuppression.
Most patients (73.3%) had a tumor, 21.2% had two to four lesions and a small number of patients had numerous tumors.
The most common areas were the head or neck (28.7%), the legs or feet (23.7%) arms or hands (21.6%).
The tumor diameter was less than 2 cm in 85%, the tumors were well-differentiated in 65.9% and the tumor was limited to the dermis in 89.5%.
Treatment included a standard distance of 69.5% and Mohs surgery at 20.2%.
In univariate analysis, risk factors for local recurrence, node metastases, disease-specific death or death of all causes included age over 70, male sex, poor tumor differentiation, and perineural invasion.
In multivariate analysis, the factors associated with a local recurrence included a tumor diameter of more than 2 cm (sub hazards ratio [SHR] 5.6, 95% CI 2.9-10.7), poor differentiation (SHR 3.3, 95% CI 1.8-5.9) and an invasion beyond the subcutaneous plane fat (SHR 7.2, 95% CI 3.4-15.3), perineural invasion (SHR 3.2, 95% CI 1.5-7) and localization at temples or ear (SHR 4.8, 95% CI 2-11.6).
Read more: How Fast Does Squamous Cell Carcinoma Spread
Together with tumor diameter, these additional risk factors were associated with node metastases:
- Poor Differentiation, SHR 6.1 (95% CI 2.5-14.9, P .001)
- Invasion beyond subcutaneous fat, SHR 9.3 (95% CI 2.8-31.1, P .001)
- Position on the temple or ear, SHR 3.8 (95% CI 1.1-13.4, P .001)
And these factors spoke in favor of disease-specific death:
- Poor Differentiation, SHR 6.7 (95% CI 2.7-16.5, P .001)
- Invasion beyond subcutaneous fat, SHR 13 (95% CI 4.3-40, P .001)
- Perineural Invasion, SHR 3.6 (95% CI 1.1-12, P = 0.03)
- Position on the temple or ear, SHR 5.9 (95% CI 1.3-26.7, P = 0.02)
- Anogenital localization observed in only nine cases was also associated with poor results, with three disease-specific deaths.
Can You Die From Squamous Cell Carcinoma
Can You Die From Squamous Cell Carcinoma, Identifying these risk factors can help physicians make decisions for treatment and help design clinical trials to develop better treatment strategies, the researchers noted.
“Optimal management of high-risk [cutaneous squamous cell carcinoma] awaits an accurate risk assessment of the results of population-based data and clinical trials that assess the benefits of modalities for disease staging and adjuvant therapy,” they concluded.
The limitations of the study concerned the relatively homogeneous population, of which only a few were immunosuppressed, the single center and the possible underreporting of local tumor recurrences.